![]() Nevertheless, quinine should be used in a small dose and cautiously, especially in the elderly and patients with renal failure, and should be avoided in patients with liver disease. Further, a dosage of 200 to 300 mg of quinine every night has not been shown to cause significant side effects. Consequently, scientific studies designed to prove or disprove the effectiveness of quinine can be subject to flaws. More important, cramp is a subjective symptom, therefore difficult to measure objectively. Most patients consider quinine beneficial for their leg cramps, which is difficult to refute by scientific data. Quinine appears to decrease the excitability of the motor end plate, thereby reducing the muscle contractility. ![]() The mechanism of this beneficial effect is obscure, however. Several double-blind, randomized, placebo-controlled studies have questioned the effectiveness of quinine in leg cramps whereas other studies have shown significantly more benefit with use of quinine in reducing the frequency and severity of cramps compared with placebo or vitamin E. Quinine sulfate, an antimalarial drug, is widely used as an effective therapy for idiopathic leg cramps. No specific cause can be identified therefore, therapy is mostly symptomatic. It is commonly nocturnal and can disturb a good night's sleep. ![]() Muscle cramps nocturnal leg cramps older population randomized controlled trial vitamin K2.Muscle cramp is a recurrent and painful condition and a common complaint among elderly subjects and patients treated with hemodialysis. The findings of this RCT will encourage the studies of vitamin K2 in musculoskeletal disorders. This randomized controlled trial (RCT) of rigorous methodological design will help to establish the effectiveness of vitamin K2 for the management of NLCs in older population. We included patients from a large university-based ambulatory clinic in. Methods: Our study was a crossover randomized double-blind placebo-controlled trial. Our objective was to evaluate the efficacy of magnesium in the treatment of nocturnal leg cramps. Our previous study has shown vitamin K2 was effective to reduce the frequency, severity, and duration of dialysis-related muscle cramps with a good safety profile. Background: Nocturnal leg cramps are a common health problem in the ambulatory setting. Nocturnal Leg Cramps (NLCs) are a common musculoskeletal disorder in the general population, but effective and safe interventions have not been established. Two hundred patients will be needed, for this two-treatment parallel design study, to achieve a probability is 90% that the study will detect a treatment difference at a two-sided 0.04 significance level, if the difference between treatments is 3.6 (difference in means between treatment arms) NLC events. The secondary outcomes include the severity and duration of NLCs in the vitamin K2 and placebo arms. The primary outcome is the difference in the mean number of NLCs per week in the vitamin K2 and placebo arms. ![]() Follow-up visits will be scheduled each week at the beginning of 4-week intervention, then participants will be visited semimonthly. Participants will be randomized to receive vitamin K2 or a similar-looking placebo for 8 weeks in a 1:1 ratio. This multicenter, randomized, double-blind, placebo-controlled clinical study will enroll older age (≥65-year-old) with two or more documented episodes of NLCs during 2 weeks of screening. Thus, the present study aims to investigate the effects of vitamin K2 for NLCs in a prospective randomized, double-blind, controlled trial. There is conflicting evidence regarding the efficacy of conventional interventions in preventing cramps. Because the precise pathophysiology of NCLs is unclear, different interventions have been proposed. Nocturnal leg cramps (NLCs) are sudden contractions of the leg muscles, usually in the posterior calf muscles at night, affecting sleep quality. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |